Diverse ansamycin derivatives from the marine-derived Streptomyces sp. ZYX-F-97 and their antibacterial activities

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成果类型：

期刊论文

作者：

Yi, Ke-Xin;Xie, Qing-Yi;Ma, Qing-Yun;Yang, Li;Dai, Hao-Fu;...

通讯作者：

Hao, YE;Zhao, YX

作者机构：

[Hao, Yu-E; Yi, Ke-Xin] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.

[Dai, Hao-Fu; Xie, Qing-Yi; Yang, Li; Ma, Qing-Yun; Zhao, You-Xing] Inst Trop Biosci & Biotechnol, Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China.

[Dai, Hao-Fu; Xie, Qing-Yi; Yang, Li; Ma, Qing-Yun; Zhao, You-Xing] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China.

通讯机构：

[Zhao, YX ] I

[Hao, YE ] U

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.

Inst Trop Biosci & Biotechnol, Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China.

Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China.

语种：

英文

关键词：

Ansamycin derivatives;Antibacterial activity;Marine-derived actinomycetes;Streptomyces sp.

期刊：

Fitoterapia

ISSN：

1971-551X

年：

2024

卷：

173

页码：

105814

DOI：

10.1016/j.fitote.2023.105814

基金类别：

CRediT authorship contribution statement Ke-Xin Yi: Visualization, Methodology, Investigation, Formal analysis. Qing-Yi Xie: Validation, Methodology, Formal analysis, Data curation. Qing-Yun Ma: Validation, Investigation. Li Yang: Validation, Supervision, Methodology, Formal analysis. Hao-Fu Dai: Validation, Supervision, Conceptualization. You-Xing Zhao: Supervision, Resources, Project administration, acquisition, Conceptualization. Yu-E Hao: Supervision, Resources, Project administration, Conceptualization.

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Four new ansamycin derivatives, named 1,19-epithio-geldanamycin A (1), 17-demethoxylherbimycin H (2), herbimycin M (3), and seco-geldanamycin B (4), together with eight known ansamycin analogues (5-12) were isolated from the solid fermentation of marine-derived actinomycete Streptomyces sp. ZYX-F-97. The structures of new compounds were elucidated by extensive spectroscopic analysis as well as nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations. All the compounds were assayed for their antibacterial activity. Among them, compounds 4, 8, and 12 exhibited remark...

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Diverse ansamycin derivatives from the marine-derived Streptomyces sp. ZYX-F-97 and their antibacterial activities

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