N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Ye-shi;Ouyang, Xin-ping;Yu, Xiao-hua;Novak, Petr;Zhou, Le;...

通讯作者：

He, Ping-ping;Yin, Kai

作者机构：

[He, Ping-ping; Chen, Ye-shi] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Ouyang, Xin-ping] Univ South China, Hengyang Med Coll, Hengyang Key Lab Neurodegenerat & Cognit Impairme, Dept Physiol,Neurosci Inst, Hengyang 421001, Hunan, Peoples R China.

[He, Ping-ping; Ouyang, Xin-ping] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Yu, Xiao-hua] Hainan Med Univ, Inst Clin Med, Affiliated Hosp 2, Haikou 460106, Hainan, Peoples R China.

[Zhou, Le; Yin, Kai; Novak, Petr] Guilin Med Univ, Affiliated Hosp 2, Guangxi Key Lab Diabet Syst Med, Guilin 541100, Peoples R China.

通讯机构：

[He, Ping-ping] U

[Yin, Kai] G

Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

Guilin Med Univ, Affiliated Hosp 2, Guangxi Key Lab Diabet Syst Med, Guilin 541100, Peoples R China.

语种：

英文

关键词：

Cardiovascular diseases;Demethylase;Epitranscriptomics;Methyltransferase;N6-methyladenosine (m6A)

期刊：

Journal of Cardiovascular Translational Research

ISSN：

1937-5387

年：

2021

卷：

期：

页码：

857-872

DOI：

10.1007/s12265-021-10108-w

基金类别：

Key Project of Hunan Provincial Department of Education (20A427). This work was supported by the grants from the National Natural Sciences Foundation of China (Nos. 81970390, 82060065), the Natural Science Foundation of Hunan Province (Nos. 2018JJ3455, 2018JJ2341, 2019JJ40249), the Key Project of the Natural Science Foundation of Guangxi Zhuang Autonomous Region, China(No. 2020GXNSFDA297011), the Foundation for Guangxi Key Laboratory of Diabetic Systems Medicine (No. 20-065-77), the Outstanding Young Aid Program for Education Department of Hunan Province (No. 18B274), the Major Project of social science achievement review committee in Hunan Province (No. XSP20ZDI013), and the Hunan Provincial Innovation Foundation For Postgraduate (No. CX20200965).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

N6-methyladenosine (m6A) is the most abundant and prevalent epigenetic modification of mRNA in mammals. This dynamic modification is regulated by m6A methyltransferases and demethylases, which control the fate of target mRNAs through influencing splicing, translation and decay. Recent studies suggest that m6A modification plays an important role in the progress of cardiac remodeling and cardiomyocyte contractile function. However, the exact roles of m6A in cardiovascular diseases (CVDs) have not been fully explained. In this review, we summarize the current roles of the m6A methylation in the ...

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