Antisense oligonucleotide suppression of human IGF-1R inhibits the growth and survival of in vitro cultured epithelial ovarian cancer cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Jie*;Li, Junjun;Zeng, Guqing;Tang, Yanxiang;Tian, Wenfang;...

通讯作者：

Tang, Jie

作者机构：

[He, Jie; Tian, Wenfang; Tang, Yanxiang; Tang, Jie] Hunan Prov Tumor Hosp, Dept Gynecol Oncol, Changsha 410006, Hunan, Peoples R China.

[Li, Junjun] Hunan Prov Tumor Hosp, Dept Pathol, Changsha 410006, Hunan, Peoples R China.

[Zeng, Guqing] Univ South China, Sch Med, Dept Gen Surg, Hengyang, Peoples R China.

[York, J. Philippe; Xia, Xuefeng] Weill Cornell Sch Med, Houston Methodist Res Inst, Houston, TX 77030 USA.

[Xia, Xuefeng] Guangzhou Med Univ, Affiliated Hosp 3, Guangzhou 510150, Guangdong, Peoples R China.

通讯机构：

[Tang, Jie] H

Hunan Prov Tumor Hosp, Dept Gynecol Oncol, Xianjiahu Rd, Changsha 410006, Hunan, Peoples R China.

语种：

英文

关键词：

Antisense;IGF-1R;Epithelial ovarian cancer

期刊：

Journal of Ovarian Research

ISSN：

1757-2215

年：

2013

卷：

期：

页码：

1-10

DOI：

10.1186/1757-2215-6-71

基金类别：

Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [09JJ5012]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101996, 81270868]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Preclinical evaluation of the anti-neoplastic activity of antisense oligonucleotide (AS) suppression of human insulin-like growth factor I receptor (IGF-IR) in human epithelial ovarian cancer (EOC). Ovarian cancer cells from 36 patients with EOC were investigated under serum-free tissue culture conditions. IGF-I production was evaluated by standard ELISA. IGF-IR and phosphorylated IRS-1, AKT, and MAP kinase expression and protein levels were evaluated by immunohistochemistry and Western blotting. Cancer cell growth and proliferation assays were performed in triplicates using MTT assay. Apoptos...

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Antisense oligonucleotide suppression of human IGF-1R inhibits the growth and survival of in vitro cultured epithelial ovarian cancer cells

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