期刊论文

Effects of ALDH2 on mitochondrial stress during ischemia - reperfusion in rats

中文

中国急救医学

1002-1949

2019

39

5

467-470

10.3969/j.issn.1002-1949.2019.05.014

81460433:国家自然科学基金 2018JJ2339:湖南省自然科学基金 2018JJ6122:湖南省自然科学基金 XJK17BGD070:湖南省教育科学规划课题

本校为第一机构

Objective To explore the effect of acetaldehyde dehydrogenase-2(ALDH2)on mitochondrial stress after the injury of intestinal ischemia/repeafusion(VR).Methods Thirty-two male Sprague-Dawley rats were randomly divided into pseudo-surgical group,IVR model group,ALDH2-siRNA group and Srambled-siRNA group.And each group had eight rats.Rat model of intestinal I/R injury was established by ligation the superior mesenteric artery blood flow for 1 h and reperfusion for 2 h.However,no ligation was performed in the pseudo-surgical group.ALDH2-siRNA group ...

Objective To explore the effect of aceteddehyde dehydrogenase -2 (ALDH2) on mitochondrial stress after the injury of intestinal ischemia/reperfusion (I/R). Methods Thirty - two male Sprague - Dawley rats were randomly divided into pseudo - surgical group, I/R model group, ALDH2 - siRNA group and Srambled - siRNA group. And each group had eight rats. Rat model of intestinal I/R injury was established by ligation the superior mesenteric artery blood flow for 1 h and reperfusion for 2 h. However, no ligation was performed in the pseudo - surgical ...