期刊论文

中文

毒理学杂志

1002-3127

2015

29

2

86-89

10.16421/j.cnki.1002-3127.2015.02.002

11275215:国家自然科学基金 11275218:国家自然科学基金

本校为第一机构

目的研究纳米四氧化三铁(nano-Fe_3O_4)对小鼠肝功能的影响。方法6 ~ 8周龄的CD-1(ICR)雄性小鼠81只,随机分为9组,分别将粒径为6.3和54.6 nm的nano-Fe_3O_4以10 mg /kg体重剂量进行尾静脉注射染毒;染毒后的1、3和7 d处死小鼠,测定小鼠肝脏系数、血清丙氨酸转氨酶(ALT) 、天冬氨酸转氨酶(AST)水平;测定小鼠肝脏谷胱甘肽(GSH)水平,谷胱甘肽过氧化物酶(GSH-Px)与超氧化物歧化酶(SOD)活性,丙二醛(MDA)含量。结果与对照组比较,染毒后3和7 d,小鼠肝脏系数降低,差异有统计学意义(P < 0. 05);血清ALT、AST水平在染毒后1 d显著增高,差异有统计学意义(P < 0. 05), 之后逐渐恢复正常水平;肝组织GSH水平在染...

Objective To study the effects of ferroferric oxide nanoparticles（ nano-Fe3O4） on liver function of mice. Methods Eighty-one 6 ~ 8 weeks old healthy CD-1（ ICR） male mice were randomly divided into 9 groups; The mice were exposed to 6. 3 nm nanoFe3O4 groups and 54. 6 nm nano-Fe3O4 nanoparticle respectively by tail vein injection at a single dose of 10 mg / kg. The animals were sacrificed respectively on 1,3 and 7 days post-injection. The serum was collected for the analysis of glutamic-pyruvic transaminase（ ALT）and glutamic-oxalacetic tran...