期刊论文

中文

毒理学杂志

1002-3127

2005

19

4

275-277

10.16421/j.cnki.1002-3127.2005.04.009

湖南省自然基金资助项目（03Jjy3029）；

本校为第一机构

目的探讨甲氧滴滴涕(Methoxychlor,MXC)对雄性大鼠生精细胞的细胞周期影响.方法用流式细胞仪检测染毒雄性大鼠生精细胞周期变化.结果随着MXC染毒时间延长,实验组G0/G1期细胞数(5、10和15 d组分别为58.4%、45.8%和43.9%)与S期细胞数(5、10和15 d组分别为21.9%、20.8%和12.7%)减少,G2/M期细胞数(5、10和15 d组分别为19.7%、33.4%和43.4%)增多(P

Objective To investigate the effect of methoxychlor（MXC） on cell cycle of germ cells in male rat. Methods The cycle change of germ cells was examined with Flow Cytometry in rat exposed to MXC. Results The cell number of G0/G1 （58.4%, 45.8% and 43.9% on 5,10 and 15 d separately） and S phase （21.9% ,20.8% and 12.7% on 5,10 and 15 d separately） decreased, but that of G2/M phase （19.7% ,33.4% and 43.4% on 5,10 and 15 d separately） increased in experimental group with extension of MXC exposure（ P 〈 0.05）. The number of hapoloid cell decre...