To determine whether the proapoptotic effect of proprotein-convertasae cubtilisin/kexin 9 related to caspase3 activation by informatics analysis. The blank control group, the transfection regent control group, the negative control group and the 80 nmol/L PCSK9 siRNA+80μg/ml oxLDL group were established simultaneously with the participation of HUVEC-12 which was incubated with 80μg/ml oxLDL for 24hr. Expression of caspase3 was measured by western blot. In order to find the similarity of sequence and the existence of a common conservative motif, comparison was made among PCSK9, caspase8 an...
