TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation

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成果类型：

期刊论文

作者：

Zhu, Jiaojiao;Ao, Xingkun;Liu, Yuhao;Zhou, Shenghui;Hou, Yifan;...

通讯作者：

Zhou, Ping-Kun;Gu, YQ

作者机构：

[Zhou, Ping-Kun; Xie, Dafei; Gu, Yongqing; Wang, Ping; Zhu, Jiaojiao; Zhou, Lin; Yan, Ziyan; Gu, YQ; Liu, Yuhao; Gao, Shanshan] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Chen, Huixi; Gu, Yongqing; Liang, Xinxin; Zhou, Shenghui; Ao, Xingkun; Gu, YQ] Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Hou, Yifan; Gu, Yongqing; Gu, YQ] Hebei Univ, Coll Life Sci, Baoding 071001, Peoples R China.

通讯机构：

[Zhou, PK; Gu, YQ ] B

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

Hebei Univ, Coll Life Sci, Baoding 071001, Peoples R China.

语种：

英文

关键词：

TNKS1BP1;Type II alveolar epithelial cells;Senescence;Radiation induced lung injury

期刊：

RESPIRATORY RESEARCH

ISSN：

1465-9921

年：

2024

卷：

期：

页码：

1-16

DOI：

10.1186/s12931-024-02914-y

基金类别：

This study was supported in part by grants from the National Natural Science Foundation of China (Grant no.82273568, 82073488, 32171238, 81773359, 82230108, 31470894).

机构署名：

本校为通讯机构

摘要：

Although recent studies provide mechanistic understanding to the pathogenesis of radiation induced lung injury (RILI), rare therapeutics show definitive promise for treating this disease. Type II alveolar epithelial cells (AECII) injury in various manner results in an inflammation response to initiate RILI. Here, we reported that radiation (IR) up-regulated the TNKS1BP1, causing progressive accumulation of the cellular senescence by up-regulating EEF2 in AECII and lung tissue of RILI mice. Senescent AECII induced Senescence-Associated Secretory Phenotype (SASP), consequently activating fibrobl...

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TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation

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