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Interaction between MicroRNA-7 and its Target Genes in Schizophrenia Patients

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成果类型:
期刊论文
作者:
Jin Zhang;Guang-ya Zhang;Jin Xu;Wen-bo Wu;Xin-yang Sun;...
通讯作者:
Zhang, L.-Y.
作者机构:
[Zhang J.] School of medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China
[Zhang G.-Y.] Department of Psychiatry, Suzhou Psychiatric Hospital, Suzhou, Jiangsu, 215101, China
[Xu J.] Administration office, No.102 Hospital of Chinese People's Liberation Army, Changzhou, Jiangsu, 213003, China
[Wu W.-B.] Department of outpatients, No.102 Hospital of Chinese People's Liberation Army, Changzhou, Jiangsu, 213003, China
[Sun X.-Y.; Zhang L.-Y.] Prevention and Treatment Center for Psychological Diseases, No.102 Hospital of Chinese People's Liberation Army, Changzhou, Jiangsu, 213003, China
通讯机构:
[Zhang, L.-Y.] P
Prevention and Treatment Center for Psychological Diseases, No.102 hospital of Chinese People's Liberation Army, North Peace Road 55, Changzhou, Jiangsu, China
语种:
英文
关键词:
Jin Zhang;Guang-ya Zhang;Jin Xu;Wen-bo Wu;Xin-yang Sun;Li-yi Zhang and Shu-ya He;Schizophrenia;miRNA-7;Target genes;Interaction
期刊:
African Journal of Psychiatry
ISSN:
1994-8220
年:
2015
卷:
18
期:
2
页码:
1-6
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Objective: To verify interaction between miRNA-7 and its target genes, and explore its possible role in schizophrenia. Methods: The hippocampal neuron cells (HT22) in mice transfected by lentiviral vector with microRNA-7 interference and over-expression were cultured, and the microRNA expression profiling of HT22 target genes were measured by quantitative RT-PCR. Results: The expression of three genes (ERBB4, GABRA6, and GAD1) increased along with the low expression of miRNA-7, and decreased along with the over-expression of microRNA-7. Express...

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