Identification of phage display peptides with affinity for the tegument of Schistosoma japonicum schistosomula

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成果类型：

期刊论文

作者：

Liu, Yan;Brindley, Paul J.;Zeng, Qingren*;Li, Yuesheng;Zhou, Jun;...

通讯作者：

Zeng, Qingren

作者机构：

[Liu, Yan; Yang, Shenghui; Zhang, Zuping; Cai, Liting; Zeng, Qingren; Chen, Yuxiao; Li, Yuesheng; Liu, Biyuan] Cent S Univ, Xiangya Sch Med, Ctr Cell & Mol Biol Expt, Changsha 410013, Hunan, Peoples R China.

[Brindley, Paul J.] George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA.

[McManus, Donald P.; Li, Yuesheng] Queensland Inst Med Res, Mol Parasitol Lab, Brisbane, Qld 4006, Australia.

[Liu, Yan] Univ S China, Sch Med, Dept Parasitol, Hengyang 421001, Peoples R China.

[Zhou, Jun] Cent S Univ, Xiangya Hosp 3, Expt Ctr, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Zeng, Qingren] C

Cent S Univ, Xiangya Sch Med, Ctr Cell & Mol Biol Expt, Tongzipo Rd 172, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Ectogenic polypeptide;M13 phage peptide ZL4 (MppZL4);Phage display technology;Schistosoma japonicum;Schistosomicidal effect

期刊：

Molecular and Biochemical Parasitology

ISSN：

0166-6851

年：

2011

卷：

180

期：

页码：

86-98

DOI：

10.1016/j.molbiopara.2011.09.001

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC:30570952]; Hunan Provincial Science Foundation [10JJ3010]; Foundation of Hunan Provincial Health [B2009051]; Central South University [2010QZZD027]; Key Projects Fund of Changsha City [K0802105-31]

机构署名：

本校为其他机构

院系归属：

医学院

公共卫生学院

摘要：

Peptides, bound to the tegument of live Schistosoma japonicum schistosomula, were differentially screened by phage display in vitro using three rounds of reverse absorption and bio-panning. Three M13 phage peptides were isolated and identified by determination of their recovery rate, immunohistochemical localization, immunoblot analysis, and their anti-schistosomal effects in vivo and in vitro. Of the three, M13 phage peptide ZL4 (MppZL4, YSGLQDSSLRLR, 1.4 kDa, pI 8.8) bound to the tegument of mechanically transformed schistosomula and to other...

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Identification of phage display peptides with affinity for the tegument of Schistosoma japonicum schistosomula

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