期刊论文

Yi, Guang-Hui

英文

Biochemical and Biophysical Research Communications

0006-291X

2012

420

1

17-23

10.1016/j.bbrc.2012.02.103

This work was supported by a Grant from the National Natural Sciences Foundation of China ( 30570958 ), and the Key Program of Research Foundation of Education Bureau of Hunan Province, China ( 09A078 ).

本校为第一且通讯机构

It is well-known that sphingosine-1-phosphate (S1P), the phospholipid content of HDL, binding to S1P receptors can raise COX-2 expression and PGI 2 release through p38MAPK/CREB pathway. In the present study we assess the action of SR-B1 initiated PI3K-Akt-eNOS signaling in the regulation of COX-2 expression and PGI 2 production in response to HDL. We found that apoA1 could increase PGI 2 release and COX-2 expression in ECV 304 endothelial cells. Furthermore, SR-B1 was found to be involved in HDL induced up-regulation of COX-2 and PGI 2. Over-ex...