Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lv, Yun-cheng;Yang, Jing;Yao, Feng;Xie, Wei;Tang, Yan-yan;...

通讯作者：

Tang, Chao-ke

作者机构：

[Zhang, Min; Liu, Dan; Tang, Chao-ke; Tan, Yu-lin; Lv, Yun-cheng; Li, Liang; He, Ping-ping; Xie, Wei; Tang, Yan-yan; Ouyang, Xin-ping; Yao, Feng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan,Prov Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Lv, Yun-cheng; Xie, Wei] Univ South China, Lab Clin Anat, Hengyang 421001, Hunan, Peoples R China.

[Yang, Jing] Univ South China, Dept Endocrinol & Metab, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Yao, Feng] Univ South China, Dept Lab Anim Sci, Hengyang 421001, Hunan, Peoples R China.

[Cayabyab, Francisco S.] Univ Saskatchewan, Coll Med, Dept Surg, Saskatoon, SK S7N 0W0, Canada.

通讯机构：

[Tang, Chao-ke] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan,Prov Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABC transporter A1;antagomir;apolipoprotein E;cholesterol;cholesterol ester;diosgenin;high density lipoprotein;liver X receptor;low density lipoprotein;microRNA;microRNA 19b;unclassified drug;ABC transporter A1;ABCA1 protein, human;ABCA1 protein, mouse;antilipemic agent;apolipoprotein E;cholesterol;diosgenin;microRNA;MIRN19 microRNA, human;MIRN19 microRNA, mouse;adult;animal cell;aorta atherosclerosis;Article;atherogenesis;atherosclerotic plaque;cholesterol metabolism;cholesterol transport;controlled study;down regulation;drug efficacy;drug mechanism;foam cell;high performance liquid chromatography;human;human cell;knockout mouse;lipid storage;macrophage;male;mouse;nonhuman;priority journal;upregulation;Western blotting;animal;aorta;Aortic Diseases;atherosclerosis;C57BL mouse;cell line;deficiency;disease model;dose response;drug effects;gene expression regulation;genetic transfection;genetics;metabolism;pathology;peritoneum macrophage;Animals;Aorta;Aortic Diseases;Apolipoproteins E;Atherosclerosis;ATP Binding Cassette Transporter 1;Cell Line;Cholesterol;Diosgenin;Disease Models, Animal;Dose-Response Relationship, Drug;Foam Cells;Gene Expression Regulation;Humans;Hypolipidemic Agents;Macrophages, Peritoneal;Male;Mice, Inbred C57BL;Mice, Knockout;MicroRNAs;Transfection

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2015

卷：

240

期：

页码：

80-89

DOI：

10.1016/j.atherosclerosis.2015.02.044

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China ( 81170278 , 81370377 , 81300224 and 81100560 ), the Hunan Provincial Natural Science Foundation of China ( 14JJ2091 ) and the Scientific Research Fund of Hunan Provincial Education Department ( 12C0339 ), China, and Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China ( 2008-244 ), the construct program of the key discipline in Hunan Province, China.

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Rationale: Diosgenin (Dgn), a structural analogue of cholesterol, has been reported to have the hypolipidemic and antiatherogenic properties, but the underlying mechanisms are not fully understood. Given the key roles of macrophages in cholesterol metabolism and atherogenesis, it is critical to investigate macrophage cholesterol efflux and development of atherosclerotic lesion after Dgn treatment. Objective: This study was designed to evaluate the potential effects of Dgn on macrophage cholesterol metabolism and the development of aortic athero...

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Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1

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