Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration

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成果类型：

期刊论文

作者：

Zhang, Tao-Lan;Chen, Wen-Kang;Huang, Xian-Peng;Zheng, Bo-Wen;Wu, Peng-Fei;...

通讯作者：

Xu, Zhun;Zou, MX

作者机构：

[Zhang, Tao-Lan] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Zou, MX; Xu, Zhun; Zou, Ming-Xiang; Huang, Xian-Peng; Zheng, Bo-Wen] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

[Chen, Wen-Kang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Orthoped Surg, Hengyang 421001, Peoples R China.

[Zheng, Bo-Wen] Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China.

[Wu, Peng-Fei] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Natl Childrens Med Ctr South Cent Reg, Dept Genet & Endocrinol, Guangzhou 510623, Peoples R China.

通讯机构：

[Zou, MX ; Xu, Z] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Intervertebral disc degeneration;MIF/ACKR3 axis;Neutrophils;Single-cell RNA sequencing;The immune microenvironment

期刊：

Translational Research

ISSN：

1931-5244

年：

2024

卷：

272

页码：

1-18

DOI：

10.1016/j.trsl.2024.05.011

基金类别：

National Natural Science Foundation of China [82003802, 82002364]; Natural Science Foundation of Hunan Province [2019JJ50542, 2023JJ50156, 2022JJ40391, 2023JJ40587, 2021JJ40509]; Hunan Provincial Natural Science Foundation for Excellent Youth Scholars [2023JJ20035]; China Scholarship Council [202106370071]; Science and technology innovation Program of Hunan Province [2023RC3172]; University of South China [20224310NHYCG04, 20224310NHYCG03]; Project for Clinical Research of Hunan Provincial Health Commission [20201978, 20201956]; Research Foundation of Education Bureau of Hunan Province [22B0441, 23B0412]; Research Foundation of Hunan Provincial Health Commission [B202304078506]; Clinical Medical Technology Innovation Guidance Project of Hunan Province [2021SK51803]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

OBJECTIVES: To unravel the heterogeneity and function of microenvironmental neutrophils during intervertebral disc degeneration (IDD). METHODS: Single-cell RNA sequencing (scRNA-seq) was utilized to dissect the cellular landscape of neutrophils in intervertebral disc (IVD) tissues and their crosstalk with nucleus pulposus cells (NPCs). The expression levels of macrophage migration inhibitory factor (MIF) and ACKR3 in IVD tissues were detected. The MIF/ACKR3 axis was identified and its effects on IDD were investigated in vitro and in vivo. RESULTS: We sequenced here 71520 single cells from 5 co...

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Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration

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