Research progress of flavonoids targeting estrogen receptor in the treatment of breast cancer

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成果类型：

期刊论文

作者：

Long, Jianling;Ye, Pengju;Yuan, Weixi;Yang, Qixian;Wang, Zhe;...

通讯作者：

Deng, Xiangping;Tang, GT

作者机构：

[Yang, Xiaoyan; Yuan, Weixi; Long, Jianling; Tang, Guotao; Tang, GT; Ye, Pengju; Xie, Zhizhong; Deng, Xiangping; Lei, Xiaoyong; Deng, XP; Yang, Qixian] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm,Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zhe] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Hongxiang] Hunan Haopifu Pharmaceut Co Ltd, Changsha, Hunan, Peoples R China.

通讯机构：

[Tang, GT ; Deng, XP] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm,Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Breast cancer;Estrogen receptor;Flavonoids;Structure-activity

期刊：

Bioorganic & Medicinal Chemistry

ISSN：

0968-0896

年：

2025

卷：

120

页码：

118106

DOI：

10.1016/j.bmc.2025.118106

基金类别：

National Natural Science Foundation of China [82404434, 82304420]; Natural Science Foundation of Hunan Province [2024JJ6405, 2023JJ40576]; Hunan Provincial Key Laboratory of Tumor Microenvironment responsive Drug Research [2019TP1041]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study; Tumor Microenvironment Responsive to Natural Product R&D Graduate Innovation Base

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Breast cancer (BC) stands as the most prevalent malignancy among women. Targeting the estrogen receptor (ER) or ER pathway is one of the important approaches for ER + BC treatment. As a class of phytoestrogens, flavonoids possess notable anti-tumor properties and hold immense potential in regulating ER signaling. In this review, we reported the recent advances in both in vitro and in vivo studies of flavonoids and their synthetic derivatives targeting the ER signaling pathway, including the target and mechanism of action of these molecules, as ...

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