期刊论文

Xiao, Xianzhong

英文

Free Radical Research

1071-5762

2011

45

11-12

1355-1365

10.3109/10715762.2011.627330

All authors of this manuscript disclose any financial and personal relationships with other people or organizations that could have influenced this work. This work was supported by grant from the Major National Basic Research Program of China (2007CB512007). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

本校为其他机构

Constitutive heat shock protein 70 (Hsc70) is a molecular chaperone that has been shown to protect cardiomyocytes against oxidative stress. However, the molecular mechanism responsible for this protection remains uncertain. To understand the mechanism associated with the myocardial protective role of Hsc70, we have embarked upon a systematic search for Hsc70-interacting proteins. Using adenosine diphosphate (ADP) affinity chromatography and mass spectrometry, we have identified α-enolase, a rate-limiting enzyme in glycolysis, as a novel Hsc70-...