Sphingopyxis sp. YF1 and metabolite astaxanthin alleviate MC-LR-induced kidney injury

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成果类型：

期刊论文

作者：

Li, Yafang;Wei, Jia;Liang, Xiaofang;Wang, Jiangping;Yan, Sisi;...

通讯作者：

Ren, Xiaoya;Yang, F

作者机构：

[Yang, F; Wei, Jia; Ren, Xiaoya; Ren, XY; Li, Yafang; Yang, Fei; Yan, Sisi; Zhan, Chunhua] Univ South China, Hengyang Med Sch, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Hunan, Peoples R China.

[Liang, Xiaofang] Anhui Med Univ, Clin Coll, Hefei 230032, Anhui, Peoples R China.

[Wang, Jiangping] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Hunan, Peoples R China.

[Zhu, Lemei] Changsha Med Univ, Sch Publ Hlth, Changsha 410219, Hunan, Peoples R China.

[Ding, Zhen] Jiangsu Prov Ctr Dis Control & Prevent, Dept Environm & Hlth, Nanjing 210009, Jiangsu, Peoples R China.

通讯机构：

[Yang, F ; Ren, XY] U

Univ South China, Hengyang Med Sch, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MC-LR;Sphingopyxis sp. YF1;Astaxanthin;Kidney injury;Bioantidotes

期刊：

Process Safety and Environmental Protection

ISSN：

0957-5820

年：

2025

卷：

197

页码：

106982

DOI：

10.1016/j.psep.2025.106982

基金类别：

This work was funded by the National Natural Science Foundations of China ( 42477468, 52400213 ); the Natural Science Foundation of Hunan Province ( 2024JJ6382 , 2025JJ30035 ). CRediT authorship contribution statement Yan Sisi: Resources, Methodology. Wang Jiangping: Resources, Methodology. Ding Zhen: Supervision, Resources. Zhu Lemei: Supervision, Resources. Li Yafang: Writing – original draft, Validation, Methodology, Data curation, Conceptualization. Liang Xiaofang: Validation, Methodology, Data curation, Conceptualization. Wei Jia: Writing – original draft, Methodology, Data curation, Conceptualization. Ren Xiaoya: Writing – review & editing, Validation, Supervision, Resources, acquisition,

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Microcystin-LR (MC-LR) is a widely distributed cyanotoxin that causes kidney injury. Our previous work identified Sphingopyxis sp. YF1 as a novel bacterial strain capable of efficiently degrading MC-LR, but its protective role and mechanisms against MC-LR-induced kidney injury remain unexplored. In this study, the bioactive metabolite of strain YF1 was identified by mass spectrometry. The beneficial effect of strain YF1 and its bioactive metabolite against MC-LR-induced kidney injury was validated in vivo and in vitro . We found strain YF1 effe...

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Sphingopyxis sp. YF1 and metabolite astaxanthin alleviate MC-LR-induced kidney injury

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