期刊论文

Xiaoya Ren

英文

Process Safety and Environmental Protection

0957-5820

2025

106982

10.1016/j.psep.2025.106982

This work was funded by the National Natural Science Foundations of China (42477468); the Hunan Province Key Research and Development Projects (2022SK2089); the Natural Science Foundation of Hunan Province, China (2024JJ6382). CRediT authorship contribution statement Yan Sisi: Resources, Methodology. Wang Jiangping: Resources, Methodology. Ding Zhen: Supervision, Resources. Zhu Lemei: Supervision, Resources. Li Yafang: Writing – original draft, Validation, Methodology, Data curation, Conceptualization. Liang Xiaofang: Validation, Methodology, Data curation, Conceptualization. Wei Jia: Writing – original draft, Methodology, Data curation, Conceptualization. Ren Xiaoya: Writing – review & editing, Validation, Supervision, Resources, acquisition,

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Microcystin-LR (MC-LR) is a widely distributed cyanotoxin that causes kidney injury. Our previous work identified Sphingopyxis sp. YF1 as a novel bacterial strain capable of efficiently degrading MC-LR, but its protective role and mechanisms against MC-LR-induced kidney injury remain unexplored. In this study, the bioactive metabolite of strain YF1 was identified by mass spectrometry. The beneficial effect of strain YF1 and its bioactive metabolite against MC-LR-induced kidney injury was validated in vivo and in vitro . We found strain YF1 effe...