Polymorphisms and haplotypes of the TGF-β1 gene are associated with risk of polycystic ovary syndrome in Chinese Han women

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成果类型：

期刊论文

作者：

Yang, Jie;Zhong, Ting;Xiao, Guohong;Chen, Yan;Liu, Jianqiao;...

通讯作者：

Xiao, Jianhua

作者机构：

[Xiao, Jianhua; Yang, Jie; Liu, Jianqiao] Univ South China, Coll Med, Dept Immunol, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Guohong; Guan, Ronghua; Du, Hongzi; Zhong, Ting; Yang, Jie; Kang, Xiangjin; Liu, Jianqiao; Chen, Yan; Lin, Yuyi] Guangzhou Med Univ, Affiliated Hosp 3, Med Ctr, Dept Reprod, Guangzhou 510150, Guangdong, Peoples R China.

[Xiao, Guohong; Du, Hongzi; Xia, Chenglai; Yang, Jie; Kang, Xiangjin; Chen, Yan; Yan, Pengke] Guangdong Prov Key Lab Reprod Med, Guangzhou 510150, Guangdong, Peoples R China.

[Xiao, Jianhua] Univ South China, Dept Immunol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, Jianhua] U

Univ South China, Dept Immunol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Transforming growth factor-beta 1 (TGF-beta 1);Gene polymorphism;Polycystic ovary syndrome (PCOS);Haplotype

期刊：

European Journal of Obstetrics & Gynecology and Reproductive Biology

ISSN：

0301-2115

年：

2015

卷：

186

页码：

1-7

DOI：

10.1016/j.ejogrb.2014.11.004

基金类别：

This study was also supported by Key discipline foundation of basic medicine of Hunan province and Hunan Provincial Key Laboratory for Special pathogens Prevention and Control [Hunan Provincial Science and Technology Department document (Approval number: 2014-5) and Hunan Provincial Education Department document (Approval number: 2012-312)].

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Objectives Transforming growth factor-beta 1 (TGF-β1) is one of the multifunctional cytokine families. It takes part in a series of physiological and pathological processes in the human body, including wound healing, tissue fibrosis and embryonic development. Recent studies have shown that TGF-β1 participates in the development of polycystic ovary syndrome (PCOS). This study was therefore designed to investigate the association of TGF-β1 polymorphism with the risk of PCOS. Study design We enrolled 328 PCOS patients and 358 healthy individual...

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Polymorphisms and haplotypes of the TGF-β1 gene are associated with risk of polycystic ovary syndrome in Chinese Han women

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