Adipocyte-derived exosomes promote the progression of triple-negative breast cancer through circCRIM1-dependent OGA activation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yuehua;Jiang, Baohong;Zeng, Lijun;Tang, Yuanbin;Qi, Xiaowen;...

通讯作者：

Wu, YM;Zhu, HB

作者机构：

[Wu, Yimou; Li, Yuehua; Wu, YM] Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zeng, Lijun; Zhu, Hongbo; Li, Yuehua; Tang, Yuanbin; Feng, Wenjie; Wan, Zhixing; Qi, Xiaowen; Xie, Liming; Zhu, HB] Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[He, Rongfang] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, YM ; Zhu, HB ] U

Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

CircCRIM1;Environmental factors;Exosomes;Immune infiltration;OGA;Triple-negative breast cancer

期刊：

Environmental Research

ISSN：

0013-9351

年：

2023

卷：

239

期：

Pt 1

页码：

117266

DOI：

10.1016/j.envres.2023.117266

基金类别：

China Postdoctoral Science Foundation [2022M711541]; Natural Science Foundation of Hunan Province [2023JJ60495, 2023JJ60496]; Key Program of Hunan Provincial Department of Education [21A0270]; Scientific Research Fund Project of Hunan Provincial Health Commission [B202303109577, D202303109450]; Clinical Medical Research "4310" Program of the University of South China [20224310NHYCG07]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Triple-negative breast cancer (TNBC) has an escalating morbidity and a dismal prognosis. Obesity has been reported to be strongly linked to adverse TNBC outcomes. Exosomes (Exos) transport RNA and proteins between cells and serve as intermediaries for cell-to-cell communication. Accumulated evidence suggests that adipose-secreted circular RNAs (circRNAs) can modulate protein glycosylation in TNBC to facilitate tumor cell outgrowth. Herein, exo-circCRIM1 expression was found to be elevated in TNBC patients with a high body fat percentage. Functional experiments demonstrated that by inhibiting m...

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Adipocyte-derived exosomes promote the progression of triple-negative breast cancer through circCRIM1-dependent OGA activation

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