Micro-environment and intracellular metabolism modulation of adipose tissue macrophage polarization in relation to chronic inflammatory diseases

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成果类型：

期刊论文

作者：

Zhu, Xiao;Tu, Yixuan;Chen, Hainan;Jackson, Ampadu O.;Patel, Vaibhav;...

通讯作者：

Yin, Kai

作者机构：

[Tu, Yixuan; Chen, Hainan; Yin, Kai; Jackson, Ampadu O.; Zhu, Xiao] Univ South China, Sch Med, Res Lab Translat Med, Hengyang, Peoples R China.

[Chen, Hainan; Yin, Kai; Zhu, Xiao] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang, Peoples R China.

[Patel, Vaibhav] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB, Canada.

[Yin, Kai] Univ South China, Res Lab Translat Med, Inst Cardiovasc Dis Res, Sch Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yin, Kai] U

Univ South China, Res Lab Translat Med, Inst Cardiovasc Dis Res, Sch Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ATMs;inflammation;macrophage polarization;metabolic diseases;obesity

期刊：

DIABETES-METABOLISM RESEARCH AND REVIEWS

ISSN：

1520-7552

年：

2018

卷：

期：

页码：

e2993-

DOI：

10.1002/dmrr.2993

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470569, 81100213]; Construct Program of the Key Discipline in Hunan Province (Basic Medical Sciences at the University of South China); Scientific Research Foundation for the Returned Overseas Chinese Scholars at the University of South ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [2015XQD49]; Scientific Research Foundation for Doctors at the University of South China [2015XQD55]; Innovation Foundation for Undergraduates of Hunan Province [2017-336]; Innovation Foundation for Postgraduates of Hunan Province [CX2017B550]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The accumulation and pro-inflammatory polarization of immune cells, mainly macrophages, in adipose tissue (AT) are considered crucial factors for obesity-induced chronic inflammatory diseases. In this review, we highlighted the role of adipose tissue macrophage (ATM) polarization on AT function in the obese state and the effect of the micro-environment and intracellular metabolism on the dynamic switch of ATMs into their pro-inflammatory or anti-inflammatory phenotypes, which may have distinct influences on obesity-related chronic inflammatory ...

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Micro-environment and intracellular metabolism modulation of adipose tissue macrophage polarization in relation to chronic inflammatory diseases

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