Photo-Facilitated Nitric Oxide-Triggered Turn-on Photodynamic Therapy for Precise Antitumor Application

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Qin, Yiliang;Gao, Hanyi;Yin, Yuting;Li, Jiayi;He, Xia;...

通讯作者：

Yuan, Yi;Hu, R;Zhang, XD

作者机构：

[Yuan, Yi; Yuan, Y; He, Xia; Hu, R; Yin, Yuting; Qin, Yiliang; Hu, Rong; Li, Jiayi] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Gao, Meng; Zhang, XD; Sun, Liying; Zhang, Xiaodong; Gao, Hanyi] Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Gao, Meng; Tian, Ying; Gao, Hanyi] Univ South China, Affiliated Hosp 7, Hunan Prov Vet Adm Hosp, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Yizhao] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, Changsha 410005, Peoples R China.

[Zeng, Zebing] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

通讯机构：

[Yuan, Y; Zhang, XD ; Hu, R ] U

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

activatable photosensitizer;anti‐tumor;endoplasmic reticulum targeting;nitric oxide;photodynamic therapy

期刊：

Advanced Healthcare Materials

ISSN：

2192-2640

年：

2025

卷：

期：

页码：

e2404265

DOI：

10.1002/adhm.202404265

基金类别：

Hunan Provincial Natural Science Foundation of China; Scientific Research Fund of Hunan Provincial Education Department [22A0287]; Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates; China (South China University of Technology) [2023B1212060003]; [2024RC3206]; [2021JJ304060]; [LINC00475]; [2023JJ40552]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

摘要：

An activatable photosensitizer with a reaction‐tunable donor/acceptor push‐pull electronic effect is designed and developed, which shows high sensitivity toward nitric oxide (NO) NO with the formation of triazole segment. Moreover, the turn‐on PDT behavior and endoplasmic reticulum (ER) targeting ability enable the developed photosensitizer good inhibition effect toward tumor cells both in vitro and in vivo, which presents high promise for precise tumor therapy in practical. Abstract Photodynamic therapy (PDT) is a powerful strategy for tumo...

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Photo-Facilitated Nitric Oxide-Triggered Turn-on Photodynamic Therapy for Precise Antitumor Application

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