Molecular mechanism and therapeutic significance of essential amino acids in metabolically associated fatty liver disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Yuting;Hu, Mengsi;Huang, Shufang;Fu, Nian

通讯作者：

Fu, N;Huang, SF

作者机构：

[Fu, Nian; Hu, Mengsi; Deng, Yuting; Fu, N] Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch,Dept Gastroenterol, Hengyang 421002, Hunan, Peoples R China.

[Huang, SF; Huang, Shufang] Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

[Fu, Nian; Fu, N] Univ South China, Affiliated Nanhua Hosp, Inst Clin Res, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Huang, SF ; Fu, N ] U

Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch,Dept Gastroenterol, Hengyang 421002, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Inst Clin Res, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

Aromatic amino acids;Branched-chain amino acids;Essential amino acids;Insulin resistance;Metabolism-associated fatty liver disease;Methionine

期刊：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ISSN：

0955-2863

年：

2024

卷：

126

页码：

109581

DOI：

10.1016/j.jnutbio.2024.109581

基金类别：

The study was supported by the Special for the Construction of Innovative Provinces in Hunan (2021SK4031), Natural Science Foundation of Hunan Province (2021JJ30628), Clinical Medical Technology Innovation Guidance Project of Hunan Province(2020SK51904), Scientific Research Project of University of South China (Documents of the university of south China [2019]02), Clinical Medical Technology Innovation Guidance Project of Hunan Province(2021SK51912), Guiding Planning Project of Hengyang

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Non-alcoholic fatty liver disease (NAFLD), also known as metabolically associated fatty liver disease (MAFLD), is a systemic metabolic disease characterized by lipid accumulation in the liver, lipid toxicity, insulin resistance, intestinal dysbiosis, and inflammation that can progress from simple steatosis to nonalcoholic steatohepatitis (NASH) and even cirrhosis or cancer. It is the most prevalent illness threatening world health. Currently, there are almost no approved drug interventions for MAFLD, mainly dietary changes and exercise to control weight and regulate metabolic disorders. Meanwh...

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Molecular mechanism and therapeutic significance of essential amino acids in metabolically associated fatty liver disease

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