Uncovering the molecular mechanisms of Qingdu Zengye Decoction in the treatment of nasopharyngeal carcinoma: an integrative investigation

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成果类型：

期刊论文

作者：

Quan, Qi;Liu, Zeyu;Ding, Ran;Lin, Yongmiao;Zhang, Sihe;...

通讯作者：

Huang, Yuanyuan;Peng, Roujun;Zhang, B

作者机构：

[Fan, Teng; Ding, Ran; Luo, Wei; Lin, Yongmiao; Liu, Zeyu; Zhang, Bei; Quan, Qi; Peng, Roujun; Huang, Yuanyuan; Su, Xin] Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, State Key Lab Oncol South China,Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou 510060, Peoples R China.

[Fan, Teng; Liu, Zeyu; Zhang, Bei; Quan, Qi; Huang, Yuanyuan; Su, Xin] Integrated Tradit Chinese & Western Med Res Ctr, Guangzhou, Peoples R China.

[Zhang, Sihe] Nankai Univ, Sch Med, Dept Cell Biol, Tianjin, Peoples R China.

[Lei, Mengjie] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang, Peoples R China.

通讯机构：

[Peng, RJ; Zhang, B ; Huang, YY] S

Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, State Key Lab Oncol South China,Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou 510060, Peoples R China.

Integrated Tradit Chinese & Western Med Res Ctr, Guangzhou, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma;Qingdu Zengye Decoction;molecular networks;multi-omics;Chinese herb medicine Abbreviations NPC;Nasopharyngeal carcinoma;EBV;Epstein-Barr virus;CCRT;concurrent chemoradiotherapy;PF;Cisplatin + fluorouracil;GP;Gemcitabine + cisplatin;PD-1;programmed cell death protein 1;TCM;traditional Chinese medicine;QZD;Qingdu Zengye Decoction

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2025

卷：

页码：

1648294

DOI：

10.3389/fphar.2025.1648294

基金类别：

Key Research and Development Plan for Science and Technology in Guangzhou [202206080012]; Traditional Medical Research Fund Project of Guangdong Province [20251070]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND: Nasopharyngeal carcinoma (NPC) remains a therapeutic challenge due to its aggressive nature and limited treatment efficacy. Traditional Chinese Medicine, particularly Qingdu Zengye Decoction (QZD), has shown clinical potential, but its mechanistic basis in NPC treatment requires elucidation. PURPOSE: This study aims to elucidate the mechanisms of action of QZD in the treatment of NPC, focusing on its multi-target regulatory effects on cell apoptosis, oncogenic signaling pathways, and tumor immune microenvironment. METHODS: An integrative approach combining computational pharmacolog...

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Uncovering the molecular mechanisms of Qingdu Zengye Decoction in the treatment of nasopharyngeal carcinoma: an integrative investigation

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