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Orbital DNA walker-driven ECL biosensing based on Ag3PO4@PTCA for ultrasensitive detection of Pb2+

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成果类型:
期刊论文
作者:
Ziyang Peng;Jingxian Li;Changxiao Song;Siyuan Yu;Futing Wang;...
通讯作者:
Ren Cai
作者机构:
[Ziyang Peng; Changxiao Song; Siyuan Yu; Futing Wang; Yifan Lyv; Ren Cai] Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo and Biosensing, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, Hunan, 410082, China
Hunan Key Laboratory of Study and Discovery of Small Targeted Molecules, School of Medicine, Hunan Normal University, Changsha, Hunan, 410013, China
[Chongyang Huang; Suping Deng; Hongfen Yang] Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China
Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
通讯机构:
[Ren Cai] M
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo and Biosensing, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, Hunan, 410082, China
语种:
英文
期刊:
Biosensors and Bioelectronics
ISSN:
0956-5663
年:
2026
卷:
293
页码:
118121
基金类别:
CRediT authorship contribution statement Ziyang Peng: Writing – original draft, Investigation. Jingxian Li: Writing – review & editing, Writing – original draft. Changxiao Song: Investigation. Siyuan Yu: Formal analysis. Futing Wang: Investigation. Chongyang Huang: Formal analysis. Suping Deng: Methodology. Yifan Lyv: Writing – original draft, Resources. Dan Yang: Supervision. Hongfen Yang: Supervision, acquisition. Ren Cai: Writing – review & editing, Writing – original draft, Supervision. Weihong Tan: Writing – review &
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
Herein, a track-based orbital DNA walker is used to design a novel ECL biosensor for the highly sensitive detection of Pb 2+ based on Ag 3 PO 4 @perylene tetracarboxylic acid (PTCA). Ag 3 PO 4 @PTCA works as the ECL emitter; K 2 S 2 O 8 acts as the co-reactant; and the DNA walker is used as the signal amplification strategy. Because Ag 3 PO 4 @PTCA exhibits a higher initial ECL luminescence signal than either Ag 3 PO 4 or PTCA alone, it improves the sensitivity, and increases the signal-to-noise ratio for the ECL biosensor. In the presence of P...

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