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LncRNA Uc.173 is a key molecule for the regulation of lead-induced renal tubular epithelial cell apoptosis

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成果类型:
期刊论文
作者:
Qin, Jiabi;Ning, Huacheng;Zhou, Yao;Hu, Yue;Huang, Bo;...
通讯作者:
Huang, Ruixue
作者机构:
[Qin, Jiabi] Cent S Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha 410078, Hunan, Peoples R China.
[Zhou, Yao; Ning, Huacheng; Wu, Yue; Huang, Ruixue; Hu, Yue] Cent S Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.
[Huang, Bo] Univ South China, Coll Publ Hlth, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Huang, Ruixue] C
Cent S Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.
语种:
英文
关键词:
lncRNA;Lead;Nephrotoxicity;Apoptosis;Transcribed ultra-conserved region
期刊:
Biomedicine & Pharmacotherapy
ISSN:
0753-3322
年:
2018
卷:
100
页码:
101-107
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
Transcribed ultra-conserved region (T-UCR) transcripts are a novel class of long non-coding RNAs (lncRNAs) transcribed from ultra-conserved region which is highly conserved in human, rat, and mouse genome. LncRNA UC.173 has been found significantly down-regulated in lead-exposed population and lead-exposed animal mode, and had an inhibitory effect on lead-induced nerve cell apoptosis. We supposed that lncRNA UC.173 had an inhibitory effect on lead-induced renal tubular epithelial cell apoptosis. Thus, the aim of our study was to explore the fun...

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