版权说明 操作指南
首页 > 成果 > 详情

RNA binding protein RPS3 mediates microglial polarization by activating NLRP3 inflammasome via SIRT1 in ischemic stroke

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Zhou, Dimi;Chen, Lin;Wang, Yuzheng;Gan, Lu;Yuan, Mei;...
通讯作者:
Chen, FF
作者机构:
[Gan, Lu; Chen, Fenfang; Yuan, Mei; Chen, Lin; Wang, Yuzheng; Zhou, Dimi; Zhang, Lei] Univ South China, Dept Neurol, Affiliated Hosp 2, 35 Jiefang Dadao, Hengyang, Hunan, Peoples R China.
通讯机构:
[Chen, FF ] U
Univ South China, Dept Neurol, Affiliated Hosp 2, 35 Jiefang Dadao, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
Ischemic stroke-Microglial;stroke-Microglial polarization-NLRP3;polarization-NLRP3 inflammasome-;RPS3-SIRT1
期刊:
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
ISSN:
1052-3057
年:
2023
卷:
32
期:
6
页码:
107132
基金类别:
statement The authors gratefully acknowledge the financial supports of University of South China Clinical Research 4310 Program.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background: Ischemic stroke is the obstruction of cerebral blood flow with a high morbidity. Microglial polarization is a contributing factor for ischemic strokeinduced injury. Here, we focused on function and mechanism of RNA binding protein RPS3 in microglial polarization after ischemic stroke. Methods: Transient middle cerebral artery occlusion (tMCAO) was conducted in SD rats. Infarct area was detected by TTC staining and neurological score was assessed. Fluorescence staining tested neuronal apoptosis and microglial differentiation. Oxygen and glucose deprivation/reoxygenation (OGD/R) was ...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com