Trisulfide Bond-Mediated Molecular Phototheranostic Platform for \"Activatable\" NIR-II Imaging-Guided Enhanced Gas/Chemo-Hypothermal Photothermal Therapy - 成果

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Trisulfide Bond-Mediated Molecular Phototheranostic Platform for "Activatable" NIR-II Imaging-Guided Enhanced Gas/Chemo-Hypothermal Photothermal Therapy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Gui-long;Liu, Fen;Li, Na;Fu, Qian;Wang, Cheng-kun;...

通讯作者：

Tan, Xiaofeng;Yang, QL;Chen, Guodong

作者机构：

[Xiao, Hao; Wu, Yinyin; Fu, Qian; Tang, Li; Li, Na; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Zhou, Wei; Wang, Wenjie; Lin, Nanyun; Wang, Feirong; Wang, Cheng-kun; Yang, Qinglai; Kang, Qiang; Tan, XF; Wu, Gui-long; Yang, Sha] Univ South China, Ctr Mol Imaging Probe, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Chen, Guodong; Yang, Qinglai] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

[Tan, Xiaofeng; Yang, Qinglai; Tan, XF] Hunan Prov Maternal & Child Hlth Care Hosp, Key Lab Birth Defect Res & Prevent, Natl Hlth Commiss, Changsha 410008, Hunan, Peoples R China.

[Tang, Li] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Hainan, Peoples R China.

[Tan, Xiaofeng; Yang, Qinglai; Tan, XF] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tan, XF; Yang, QL ; Chen, GD] U

Univ South China, Ctr Mol Imaging Probe, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

Hunan Prov Maternal & Child Hlth Care Hosp, Key Lab Birth Defect Res & Prevent, Natl Hlth Commiss, Changsha 410008, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

activatable fluorescence imaging;chemodynamic therapy;gas therapy;glutathione depletion;hypothermal photothermal therapy (HPTT);near-infrared II;photoinduced electron transfer

期刊：

Advanced Science

ISSN：

2198-3844

年：

2023

卷：

期：

页码：

2304104-

DOI：

10.1002/advs.202304104

基金类别：

Q.Y. acknowledges financial support from the National Natural Science Foundation of China (22374065), the National Natural Science Foundation of China (81801749), the Science and Technology Innovation Program of Hunan Province "Huxiang Young Talents Plan" [81801749]; National Natural Science Foundation of China [2021RC3106]; Science and Technology Innovation Program of Hunan Province "Huxiang Young Talents Plan" [2022SK2053]; Key Research and Development Program of Hunan Province, China [2022JJ40361]; Natural Science Foundation of Hunan Province of China [22B0409]; Scientific Reseaech Fund of Hunan Province Education Department [21A0258]; Scientific research key project of Hunan Education Department [2021JJ70039]; Natural Science Foundation of Hunan Province (Joint project of Science and Health) [20201064, 20201919]; Scientific research Project of Health Commission of Hunan Province [2020SK51817]; Hunan Provincial Clinical Medical Technology Innovation Guide Project [20224310NHYCG01, 20214310NHYPY05]; University of South China Clinical Research 4310 Program [4310]; Clinical Medical Research Project [20214310NHYPY01]; University of South China; Medical Instrument and Equipment Technology Laboratory of Hengyang Medical College

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Tumor microenvironment (TME)-triggered phototheranostic platform offers a feasible strategy to improve cancer diagnosis accuracy and minimize treatment side effects. Developing a stable and biocompatible molecular phototheranostic platform for TME-activated second near-infrared (NIR-II) fluorescence imaging-guided multimodal cascade therapy is a promising strategy for creating desirable anticancer agents. Herein, a new NIR-II fluorescence imaging-guided activatable molecular phototheranostic platform (IR-FEP-RGD-S-S-S-Fc) is presented for actively targeted tumor imaging and hydrogen sulfide (H...

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Trisulfide Bond-Mediated Molecular Phototheranostic Platform for "Activatable" NIR-II Imaging-Guided Enhanced Gas/Chemo-Hypothermal Photothermal Therapy

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