期刊论文

中文

中国生化药物杂志

1005-1678

2012

33

3

241-243,247

湖南省衡阳市科技局资助项目（2009ks33）；

本校为第一机构

目的观察甲壳低聚糖(COS)对注射小剂量链脲佐菌素(STZ)及饲高糖高脂大鼠血糖的影响。方法大鼠随机分为2组:正常对照组10只,喂基础饲料;造模组40只,经腹腔注射小剂量STZ后,用基础饲料喂养2周,挑选葡萄糖耐量异常者20只又随机分为2组:高糖高脂对照组10只和COS干预组10只,两组均用高糖高脂饲料喂养,同时COS干预组用COS溶液灌胃给药。各组连续观察16周,定期测定体重、空腹血糖及胰岛素水平,实验结束前通过葡萄糖耐量试验来观察胰岛β-细胞功能变化。结果 COS干预组与高糖高脂组比较,体重、空腹血糖和胰岛素水平差异显著(P

Purpose To study the effects of Chitooligosaccharide（COS） on the blood glucose in STZ-injected and high fat/high sucrose-fed Wistar rats.Methods Wistar rats with similar body weight were randomized into two groups：a normal group and an animal model group.After the animal model group was injected STZ（1%STZ 30 mg/kg,ip）for 2 weeks,the animals with impaired glucose tolerance were randomized into two groups：a high-fat/high-sucrose-fed group and a group which was fed high-fat and high-sucrose diet and COS.The treatment with COS lasted for 14 w...