期刊论文

中文

中国生化药物杂志

1005-1678

2009

30

3

178-180

国家重点基础研究发展项目“心血管疾病发病和防治的基础研究”（973,2006CB503808）；

本校为第一机构

目的 观察Neu-P11(一种新型的褪黑素受体激动剂),对高糖高脂喂养的SD大鼠体重及脂肪的影响.方法 高糖高脂喂养SD大鼠5个月,建立肥胖动物模型.分组给予腹腔注射生理盐水、褪黑素(4 mg/kg)、Neu-P11(10 mg/kg),每周监测体重和食物摄入量.实验末处死动物,分离腹部脂肪组织并称重.结果 与生理盐水组比较,Neu-P11或褪黑素处理组肥胖大鼠体重的增长明显受到抑制,腹部脂肪减少,各组相对摄食(每100 g体重摄食量)无明显差异.结论 Neu-P11能降低高糖高脂喂养大鼠的体重增长和脂肪沉积.

Purpose To investigate the effect of Neu-P11, a novel melatonin agonist, on the weight and fat distribution in the high-fat/high-sucrose diet （HFSD） induced obesity model of rats. Methods Obesity models of rats were constructed by feeding high-fat/high-sucrose diet for 5 months, and then they received an intraperitoneal injection at 18：00 every day,of saline, melatonin and Neu-Pll respectively. Weight was closely paid attention every week. Results Rats were sacrificed at the end of 8th week and retroperitoneal fat was dissected and weighed. ...