期刊论文

中文

中国生化药物杂志

1005-1678

2001

22

1

21-22

10.3969/j.issn.1005-1678.2001.01.008

本校为第一机构

目的　研究水溶性壳聚糖对抗肿瘤活性因子和NK 细胞活 性的影响。方法　分别用不同浓度水溶性壳聚糖腹腔注射荷瘤 小鼠 ，然后测定巨噬细胞一氧化氮(NO)、肿瘤坏死因子(TNF)的生成，以及脾细胞γ-干扰素(IF N-γ)和NK细胞活性。结果　水溶性壳聚糖有显著地促进荷瘤 小鼠NO 、TNF、IFN-γ的生成，提高NK细胞活性。与对照相比P＜0.01。结论　水溶性壳聚糖能提高荷瘤小鼠的免疫功能。

Purpose　The aim is to study the effects of solubl e chit osan on antitumor factors and NK cell activity in rats.Methods　The level of NO、TNF produced by peritoneal macrophages,IFN-γ production and NK ce ll activity of spleen was detected,after different concentrations of chitosan we re injected into the sarcoma 180 rats peritoneally.Results　Th e cont ents of NO、TNF、IFN-γ and NK cell activity in sacroma 180 rats were significa ntly higher in the chitosan groups than those in the control group (P＜0.01) .Conclusion　...