The demand for high-performance propulsion systems in deep space exploration has accelerated improvements in the design of nuclear thermal propulsion reactors (NTPRs). Existing methods for designing NTPRs lack a systematic and integral approach. This study proposes a multi-objective design optimization method for NTPRs to develop a core that offers high thrust capabilities, high specific impulse, extended service life, and reduced weight. A heat transfer model is first constructed between assemblies based on their thermal interactions, after which it is integrated with a two-dimensional assemb...