Recently, anisotropic black phosphorus (BP) has been reported to have significant physical and mechanical properties, and BP-based mass sensors have the latent applications in detecting the mass of nanoparticles attached on BP. In this paper, an orthotropic plate model (OPM) attached concentrated mass and molecular dynamics (MD) simulations are adopted to investigate the dynamic characteristics of rectangular single-layered BP-based (RSLBP-based) mass sensors. The influences of mass, position of the attachment and RSLBP size on the fundamental frequency of RSLBP-based mass sensor are discussed...