期刊论文

英文

Cancer

0008-543X

2023

129

11

1649-1661

10.1002/cncr.34729

Science and Technology Innovation Program of Hunan Province [2021RC2038]; Natural Science Foundation of Hunan Province of China [2021JJ40823, 2021JJ80072]; China Postdoctoral Science Foundation [2021T140755, 2021M703649]; Science and Technology Innovation Project of Hengyang City [202250045225]

本校为第一机构

With the continuous cognition of the relationship between tumor cells and tumor immune microenvironment, immunotherapy based on the immune checkpoint blockade has achieved great breakthroughs, led to improved clinical outcomes, and prolonged survival for cancer patients in recent years. Nevertheless, the de novo or acquired resistance to immunotherapy has greatly counteracted the efficacy, leading to a 20%-40% overall response rate. Thus, further in-depth understanding of the regulation of the tumor microenvironment and antitumor immunity is urgently warranted. Ubiquitination-mediated protein ...