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miR-23b-3p and miR-125b-5p downregulate apo(a) expression by targeting Ets1 in HepG2 cells

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成果类型:
期刊论文
作者:
Zeng, Jun-fa;Zeng, Zhao-lin;Zhang, Kai;Zhao, Yue;Liu, Ya-mi;...
通讯作者:
Wang, Zuo
作者机构:
[Zeng, Jun-fa; Zhang, Kai] Univ South China, Hosp 2, Hengyang 421001, Hunan, Peoples R China.
[Zeng, Zhao-lin; Zhao, Yue; Chen, Jiao-jiao; Jiang, Zhi-sheng; Wei, Dang-heng; Liu, Ya-mi; Wang, Zuo] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
[Tong, Hai] Univ South China, Hosp 1, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Wang, Zuo] U
Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
atherosclerosis;Lipoprotein (a);miR-23b-3p;miR-125b-5p
期刊:
Cell Biology International
ISSN:
1065-6995
年:
2018
卷:
42
期:
3
页码:
313-323
基金类别:
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Construct Program of the Key Discipline in Hunan Province; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [15C1201]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
High concentrations of plasma lipoprotein(a) [Lp(a)] have been inferred to be an independent risk factor for cardiovascular and cerebrovascular diseases, such as coronary artery diseases, restenosis, and stroke. Apolipoprotein(a) [apo(a)] is one of the most important components of Lp(a) and contributes greatly to the increased concentration of plasma Lp(a). As a critical positive transacting factor of apo(a) gene, Ets1 has been proven as a target gene of several miRNAs, such as miR-193b, miR-125b-5p, miR-200b, miR-1, and miR-499. In this study,...

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