Changsha Central Hospital Affiliated to University of South China Foundation of key Program [YNKY202305, YNKY202204]; National Natural Science Foundation of China [82003870]; Natural Science Foundation of Changsha [kq2014012]; Scientific Research Project of Education Department of Hunan Province [23B0438]; Scientific and technological innovation project of Hunan Province [2021SK53407]
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
PURPOSE: Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions related to first-line anti-tuberculosis drugs in pediatric tuberculosis patients. This study aims to develop an automatic machine learning (AutoML) model for predicting the risk of anti-tuberculosis drug-induced liver injury (ATB-DILI) in children. METHODS: A retrospective study was performed on the clinical data and therapeutic drug monitoring (TDM) results of children initially treated for tuberculosis at the affiliated Changsha Central Hospital of University of South China. After the featu...
