期刊论文

中文

系统仿真学报

1004-731X

2018

30

3

880-885

10.16182/j.issn1004731x.joss.201803014

13JJ3076:湖南省自然科学基金 14A127:湖南省教育厅重点项目

本校为第一机构

超声场中利用超声造影剂微泡UCA(ultrasound contrast agent)与凹球面间的相互作用来了解微泡在血管壁附近的声响应。基于“虚像法”及壁面的声反射效应,建立了一个UCA微泡在凹球形面内的动力学模型,通过数值计算分析了受束微泡的动力学行为。结果表明:在壁面附近时微泡振动受到压制,且刚性壁面对微泡振动的抑制比柔性壁面强;凹球面半径越小,或凹球面中心角越大,微泡振动越易受到抑制;在完全封闭球面内,球面半径越大,对微泡振动影响越弱。该模型为理解超声微泡在血管内的动力学响应及其在超声影像和药物传递中的应用提供理论参考。

The interactions between an ultrasound contrast agent (UCA) microbubble and a concave surface can be applied to understanding of the response of the UCA near blood vessel wall in ultrasound field. A dynamics model of microbubble near a concave wall is presented by a virtual image method and the acoustic reflection effects of the surface. The dynamic behavior of the microbubble is analyzed by numerical calculation. The results show that the microbubble vibration is suppressed near the wall. Inhibitory effects to microbubble vibration near rigid wall are stronger than that of near elastic wall. ...