期刊论文

Research Progress on Near Infrared II Technology for in Vivo Imaging

Yang Qinglai;Chen Minwen

中文

化学学报

0567-7351

2020

78

5

373-381

10.6023/A20020045

* E-mail: ncuedu@126.com; qingyu513@126.com Received February 26, 2020; published April 10, 2020. Project supported by the National Natural Science Foundation of China (No. 81801749) and Shenzhen Basic Research Funding (Nos. JCYJ20170307151634428, JCYJ20170817152825894). 项目受国家自然科学基金(No. 81801749)和深圳市基础研究项目(Nos. JCYJ20170307151634428, JCYJ20170817152825894)资助.

本校为第一且通讯机构

近红外二区(NIR II,1000~1700 nm)生物成像作为近年来新生的光学成像技术,相对于传统的近红外一区(NIR I,750~900 nm)和可见光(Vis,400~750 nm)成像,由于其荧光波长更长,生物组织的自发荧光背景更低,光子散射值更低,其组织穿透深度更深,该技术更适合于活体原位成像.本文综述了近红外二区荧光成像技术的发展及其在活体成像方面的应用,总结了各项技术的特点,最后对该研究方向的发展前景进行了展望,指出通过化学材料、光电仪器和多模态技术等多方面的持续发展,有望推动近红外二区活体成像技术的临床转化.

Near infrared II (NIR Ⅱ, 1000~1700 nm) biological imaging, as a new developing optical imaging technology in recent years, has longer fluorescence wavelength compared with the traditional near infrared I (NIR I, 750~900 nm) and visible light (Vis, 400~750 nm) imaging. Due to the longer emission wavelength, weaker interference by light scattering and tissue autofluorescence, result in higher temporal and spatial resolution with deeper tissue penetration. This technology is more suitable for in vivo imaging in situ. In this review, we mainly int...