Piromelatine decreases triglyceride accumulation in insulin resistant 3T3-L1 adipocytes: Role of ATGL and HSL

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成果类型：

期刊论文

作者：

Wang, Ping-Ping;She, Mei-Hua;He, Ping -Ping;Chen, Wu-Jun;Laudon, Moshe;...

通讯作者：

Yin, Wei-Dong

作者机构：

[Xu, Xuan-Xuan; He, Ping -Ping; Yin, Wei-Dong; Chen, Wu-Jun; Wang, Ping-Ping] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Yin, Wei-Dong; She, Mei-Hua] Univ South China, Dept Biochem & Mol Biol, Sch Life Sci & Technol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Wu-Jun] Univ South China, Inst Pharm, Hengyang 421001, Hunan, Peoples R China.

[Chen, Wu-Jun] Univ South China, Inst Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Laudon, Moshe] Neurim Pharmaceut Ltd, Drug Discovery, Tel Aviv, Israel.

通讯机构：

[Yin, Wei-Dong] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

3T3-L1 adipocyte;ATGL HSL;Ca2+;Insulin resistance;Piromelatine;Triglyceride

期刊：

Biochimie

ISSN：

0300-9084

年：

2013

卷：

期：

页码：

1650-1654

DOI：

10.1016/j.biochi.2013.05.005

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81270296 and 81200590 ).

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Piromelatine, a novel investigational multimodal sleep medicine, is developed for the treatment of patients with primary and co-morbid insomnia. Piromelatine has been shown to inhibit weight gain and improve insulin sensitivity in high-fat/high-sucrose-fed (HFHS) rats. Considering that piromelatine has also been implicated in lowering of triglyceride levels in HFHS rats, this work elucidated whether this effect involves in the regulation of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) in triglyceride (TG) metabolism. In...

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Piromelatine decreases triglyceride accumulation in insulin resistant 3T3-L1 adipocytes: Role of ATGL and HSL

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