A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer

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成果类型：

期刊论文

作者：

Wu, Song;Lu, Jibu;Zhu, Hongbo;Wu, Feiyue;Mo, Yunxian;...

通讯作者：

Tang, HL;Li, YH;Lin, H

作者机构：

[Lu, Jibu; Song, Cailu; Xie, Xiaoming; Liu, Lingrui; Tang, HL; Tang, Hailin; Mo, Yunxian; Wu, Song] Sun Yat Sen Univ, Canc Ctr, Guangdong Prov Clin Res Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China.

[Li, YH; Zhu, Hongbo; Li, Yuehua; Xie, Liming] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang, Peoples R China.

[Wu, Feiyue] Guizhou Prov Peoples Hosp, Guiyang, Peoples R China.

[Lin, Huan; Tang, Hailin] Guangzhou Med Univ, Affiliated TCM Hosp, Guangzhou, Peoples R China.

通讯机构：

[Tang, HL ] S

[Li, YH ] U

[Lin, H ] G

Sun Yat Sen Univ, Canc Ctr, Guangdong Prov Clin Res Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang, Peoples R China.

语种：

英文

关键词：

Autophagy;Circular RNAs;Competitive endogenous RNAs;Triple-negative breast cancer;circKIF4A

期刊：

Cancer Letters

ISSN：

0304-3835

年：

2024

卷：

581

页码：

216508

DOI：

10.1016/j.canlet.2023.216508

基金类别：

National Natural Science Foundation of China [82273399]; Medicine Foundation of Wu Jieping [32067502022-3-58]; Natural Science Foundation of Guangdong [2022A1515012213]; Natural Science Foundation of Hunan Province [2023JJ60496]; Clinical Medical Research 4310 Program of the University of South China [20224310NHYCG07]; Science and Technology Foundation of Hunan Province [2021SK51818]

机构署名：

本校为通讯机构

摘要：

Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression is greatly facilitated by circKIF4A, but uncertainty remains regarding its role in TNBC brain metastasis and the molecular mechanism. In this study, we found notable upregulation of circKIF4A in TNBC cell lines and brain metastases. Inhibition of circKIF4A impaired the ability of TNBC to proliferate, migrate, and cause brain metastasis. Luciferase reporter assays confirmed that circKIF4A competed for binding to miR-637 with STAT3 3' U...

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A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer

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