The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fan, Hui;Liu, Jiyuan;Hu, Xiangyan;Cai, Jiye;Su, Bo;...

通讯作者：

Jiang, JH

作者机构：

[Su, Bo; Jiang, Jinhuan; Liu, Jiyuan; Jiang, JH; Fan, Hui; Hu, Xiangyan] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Su, Bo; Jiang, Jinhuan; Jiang, JH] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang, Hunan, Peoples R China.

[Cai, Jiye] Jinan Univ, Dept Chem, Guangzhou 510632, Peoples R China.

通讯机构：

[Jiang, JH ] U

Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

XIAP;Tumor;XIAP inhibitor;Apoptotic

期刊：

Apoptosis

ISSN：

1360-8185

年：

2025

页码：

1-14

DOI：

10.1007/s10495-025-02101-4

基金类别：

Scientific Research Fund of Hunan Provincial Education Department; Hunan Natural Science Foundation of China for Young Scientists [2021JJ40474]; Fund of Doctoral Initiation of University of South China [190XQD141]; [23A0316]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

X-linked inhibitor of apoptosis protein (XIAP) is the most potent endogenous member of the inhibitor of apoptosis protein family. XIAP exerts its anti-apoptotic effects by inhibiting both the death receptor pathway and mitochondrial pathway of apoptosis through various mechanisms such as directly binding to caspases, activating the nuclear factor kappa B (NF-κB) pathway, and other signaling pathways. These processes are closely related to tumor development and progression, making XIAP a therapeutic target for various types of cancer. This arti...

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The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

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