The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

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成果类型：

期刊论文

作者：

Fan, Hui;Liu, Jiyuan;Hu, Xiangyan;Cai, Jiye;Su, Bo;...

通讯作者：

Jiang, JH

作者机构：

[Su, Bo; Jiang, Jinhuan; Liu, Jiyuan; Jiang, JH; Fan, Hui; Hu, Xiangyan] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Su, Bo; Jiang, Jinhuan; Jiang, JH] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang, Hunan, Peoples R China.

[Cai, Jiye] Jinan Univ, Dept Chem, Guangzhou 510632, Peoples R China.

通讯机构：

[Jiang, JH ] U

Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

XIAP;Tumor;XIAP inhibitor;Apoptotic

期刊：

Apoptosis

ISSN：

1360-8185

年：

2025

卷：

期：

页码：

1202-1215

DOI：

10.1007/s10495-025-02101-4

基金类别：

Scientific Research Foundation of Hunan Provincial Education Department, (23A0316) Scientific Research Foundation of Hunan Provincial Education Department National Natural Science Foundation of China, NSFC, (2021JJ40474, 190XQD141) National Natural Science Foundation of China, NSFC

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

X-linked inhibitor of apoptosis protein (XIAP) is the most potent endogenous member of the inhibitor of apoptosis protein family. XIAP exerts its anti-apoptotic effects by inhibiting both the death receptor pathway and mitochondrial pathway of apoptosis through various mechanisms such as directly binding to caspases, activating the nuclear factor kappa B (NF-κB) pathway, and other signaling pathways. These processes are closely related to tumor development and progression, making XIAP a therapeutic target for various types of cancer. This arti...

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The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

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