Enhanced immune response and protective efficacy of a Treponema pallidum Tp92 DNA vaccine vectored by chitosan nanoparticles and adjuvanted with IL-2

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成果类型：

期刊论文

作者：

Zhao, Feijun;Wu, Yimou;Zhang, Xiaohong;Yu, Jian;Gu, Weiming;...

通讯作者：

Wang, Shiping

作者机构：

[Zhao, Feijun; Liu, Shuangquan; Wang, Shiping] Cent S Univ, Dept Parasitol, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[Wu, Yimou; Yu, Jian; Zhao, Feijun; Zeng, Tiebing; Zhang, Yuejun] Univ S China, Pathogen Biol Inst, Sch Med, Hengyang, Peoples R China.

[Zhang, Xiaohong] Univ S China, Dept Histol & Embryol, Sch Med, Hengyang, Peoples R China.

[Gu, Weiming] Skin Dis & STD Hosp, Shanghai, Peoples R China.

通讯机构：

[Wang, Shiping] C

Cent S Univ, Dept Parasitol, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Treponema pallidum (Tp);membrane protein;Tp92;IL-2;CS;nucleic acid vaccine

期刊：

Human Vaccines

ISSN：

1554-8600

年：

2011

卷：

期：

页码：

1083-1089

DOI：

10.4161/hv.7.10.16541

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30800996]; Science and Technology Department Key Foundation of Hunan Province in China [2010FJ2008]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Aims: In this study, the immune-modulatory and protective efficacy of using an interleukin-2 (IL-2) expression plasmid as a genetic adjuvant and chitosan (CS) nanoparticles as vectors to enhance a Tp92 DNA vaccine candidate- were investigated in a Treponema pallidum (Tp)rabbit challenge model. Methods：Male New Zealand white rabbits were randomly assigned to groups (n = 18/group) and immunized intramuscularly with pTp92 based plasmid DNA constructs (100 μg of DNA/rabbit/immunization). Two weeks before Tp challenge (Week 8), three rabbits from ...

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Enhanced immune response and protective efficacy of a Treponema pallidum Tp92 DNA vaccine vectored by chitosan nanoparticles and adjuvanted with IL-2

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