Interaction Between microRNA and DNA Methylation in Atherosclerosis

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成果类型：

期刊论文

作者：

Tao, Jun;Xia, Linzhen;Cai, Zemin;Liang, Lingli;Chen, Yanjun;...

通讯作者：

Meng, Jun;Wang, Zuo

作者机构：

[Chen, Yanjun; Tao, Jun; Xia, Linzhen; Liang, Lingli; Wang, Zuo] Univ South China, Hengyang Med Coll, Hunan Int Sci & Technol Cooperat Base Arterioscle, Key Lab Arteriosclerol Hunan Prov,Inst Cardiovasc, Hengyang, Peoples R China.

[Cai, Zemin] Univ South China, Dept Pediat, Affiliated Hosp 1, Hengyang, Peoples R China.

[Meng, Jun] Univ South China, Funct Dept, Affiliated Hosp 1, 61 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zuo] Univ South China, Heng Yang Med Sch, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Changsheng Rd, Hengyang City 421001, Peoples R China.

通讯机构：

[Meng, Jun; Wang, Zuo] U

Univ South China, Funct Dept, Affiliated Hosp 1, 61 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Heng Yang Med Sch, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Changsheng Rd, Hengyang City 421001, Peoples R China.

语种：

英文

关键词：

DNA methylation;DNMTs;TET2;VSMCs;atherosclerosis;endothelia;hydroxymethylation;inflammation;microRNA

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2021

卷：

期：

页码：

101-115

DOI：

10.1089/dna.2020.6138

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81970389]; Natural Science Foundation of Hunan Province ChinaNatural Science Foundation of Hunan Province [2019JJ50531, 2020JJ4541]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Atherosclerosis (AS) is a chronic inflammatory disease accompanied by complex pathological changes, such as endothelial dysfunction, foam cell formation, and vascular smooth muscle cell proliferation. Many approaches, including regulating AS-related gene expression in the transcriptional or post-transcriptional level, contribute to alleviating AS development. The DNA methylation is a crucial epigenetic modification in regulating cell function by silencing the relative gene expression. The microRNA (miRNA) is a type of noncoding RNA that plays an important role in gene post-transcriptional regu...

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Interaction Between microRNA and DNA Methylation in Atherosclerosis

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