GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-κB signalling pathway

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成果类型：

期刊论文

作者：

Chen, Xiangheng;Huang, Qiuling;Feng, Juling;Xiao, Zhongsheng;Zhang, Xiaoling;...

通讯作者：

Zhao, Lei

作者机构：

[Xiao, Zhongsheng; Chen, Xiangheng; Zhang, Xiaoling; Huang, Qiuling; Zhao, Lei] Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Feng, Juling] Univ South China, Heng Yang Med Sch, Res Lab Translat Med, Hengyang, Peoples R China.

通讯机构：

[Zhao, Lei] U

Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

betulic acid;cryopyrin;gasdermin D;glucagon like peptide 1;immunoglobulin enhancer binding protein;inflammasome;interleukin 18;interleukin 1beta;interleukin 1beta converting enzyme;liraglutide;membrane protein;messenger RNA;sodium chloride;unclassified drug;cryopyrin;glucagon like peptide 1;immunoglobulin enhancer binding protein;inflammasome;interleukin 1beta;Nlrp3 protein, rat;animal experiment;animal model;animal tissue;Article;atherosclerosis;controlled study;in vivo study;infant;inflammation;male;NF kB signaling;nonhuman;obesity;pathogenesis;perivascular adipose tissue;protein cleavage;protein expression;rat;real time polymerase chain reaction;upregulation;Western blotting;Zucker diabetic fatty rat;adipose tissue;animal;genetics;inflammation;Zucker rat;Adipose Tissue;Animals;Glucagon-Like Peptide 1;Inflammasomes;Inflammation;Interleukin-1beta;NF-kappa B;NLR Family, Pyrin Domain-Containing 3 Protein;Rats;Rats, Zucker

期刊：

Journal of International Medical Research

ISSN：

0300-0605

年：

2021

卷：

期：

页码：

030006052199298

DOI：

10.1177/0300060521992981

基金类别：

This work was supported by the National Natural Science Foundation of China (grant No. 81900488), Natural Science Foundation of Hunan Province (grant No. 2019JJ50549), Technological Innovation Guidance Program of Hunan Province (grant No. 2018SK51605) and Hengyang Science and Technology Board Program (grant No. HKF2019Y47N207).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Objectives: To study the effect of glucagon-like peptide 1 (GLP-1) on NLR family pyrin domain containing 3 (NLRP3) inflammasome-induced inflammation in perivascular adipose tissue (PVAT) of Zucker diabetic fatty (ZDF) rats and the underlying role of nuclear factor (NF)-κB signalling. Methods: Thirty ZDF rats were randomly divided into three study groups: DM (0.9% saline, subcutaneously); DM+GLP-1 (liraglutide, s.c.); and NF-κB+GLP-1 (betulinic acid then liraglutide, s.c.). Ten Zucker lean rats were examined as normal controls. PVAT from ZDF (...

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GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-κB signalling pathway

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