Progress on the role of extrachromosomal DNA in tumor pathogenesis and evolution

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xing, Jichen;Ning, Qian;Tang, Diya;Mo, Zhongcheng;Lei, Xiaoyong;...

通讯作者：

Tang, Shengsong

作者机构：

[Lei, Xiaoyong; Tang, Shengsong; Xing, Jichen] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.

[Lei, Xiaoyong; Tang, Shengsong; Xing, Jichen] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Tang, Shengsong; Xing, Jichen; Ning, Qian] Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua, Peoples R China.

[Tang, Diya] Cent South Univ, Dept Med Oncol, Xiangya Hosp, Changsha, Peoples R China.

[Mo, Zhongcheng] Guilin Med Univ, Coll Basic Med, Inst Basic Med Sci, Guilin, Guangxi, Peoples R China.

通讯机构：

[Tang, Shengsong] U

Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

drug resistance;extrachromosomal DNA;oncogene amplification;tumor heterogeneity

期刊：

Clinical Genetics

ISSN：

0009-9163

年：

2021

卷：

期：

页码：

503-512

DOI：

10.1111/cge.13896

基金类别：

Jichen Xing and Qian Ning contributed equally to this work Hunan Provincial Natural Science Foundation of China, Grant/Award Number: 2019JJ50416; Hunan Provincial Science and Technology Plan Key Projects of China, Grant/Award Number: 2017SK2183; National Natural Science Foundation of China, Grant/Award Number: 30270684; Scientific Research Fund of Hunan Provincial Education Department, Grant/Award Number: 18C1133

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The amplification of oncogenes on extrachromosomal DNA (ecDNA) provides a new mechanism for cancer cells to adapt to the changes in the tumor microenvironment and accelerate tumor evolution. These extrachromosomal elements contain oncogenes, and their chromatin structures are more open than linear chromosomes and therefore have stronger oncogene transcriptional activity. ecDNA always contains enhancer elements, and genes on ecDNA can be reintegrated into the linear genome to regulate the selective expression of genes. ecDNA lacks centromeres, and the inheritance from the parent cell to the dau...

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Progress on the role of extrachromosomal DNA in tumor pathogenesis and evolution

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