CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3beta/beta-catenin(T120)/TCF21 pathway.

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成果类型：

期刊论文

作者：

Gao, Jia-Hui;He, Lin-Hao;Yu, Xiao-Hua;Zhao, Zhen-Wang;Wang, Gang;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Zhao, Zhen-Wang; Zhou, Li; Yu, Xiao-Hua; Wang, Gang; Gao, Jia-Hui; Zou, Jin; Wan, Xiang-Jun] Univ South China, Hengyang Med Coll,Hunan Int Sci & Technol Coopera, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang, Hunan, Peoples R China.

[Wen, Feng-Jiao; He, Lin-Hao] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Sch Pharm, Hengyang, Hunan, Peoples R China.

[Wen, Feng-Jiao; He, Lin-Hao] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Life Sci Coll, Hengyang, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Hengyang Med Coll,Hunan Int Sci & Technol Coopera, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

ATP binding cassette transporter A1;CXC chemokine ligand 12;CXC chemokine receptor 4;cholesterol efflux;glycogen synthase kinase 3beta;transcription factor 21

期刊：

Journal of Lipid Research

ISSN：

0022-2275

年：

2019

卷：

期：

页码：

2020-2033

DOI：

10.1194/jlr.RA119000100

基金类别：

Hunan Provincial Innovation Foundation for Postgraduate Grant [CX20190750]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81770461]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

CXC chemokine ligand 12 (CXCL12) is a member of the CXC chemokine family and mainly acts on cell chemotaxis. CXCL12 also elicits a proatherogenic role, but the molecular mechanisms have not been fully defined yet. We aimed to reveal if and how CXCL12 promoted atherosclerosis via regulating lipid metabolism. In vitro, our data showed that CXCL12 could reduce ABCA1 expression, and it mediated cholesterol efflux from THP-1-derived macrophages to apoA-I. Data from the luciferase reporter gene and chromatin immunoprecipitation assays revealed that transcription factor 21 (TCF21) stimulated the tran...

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CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3beta/beta-catenin(T120)/TCF21 pathway.

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