A novel immune checkpoint-related signature for prognosis and immune analysis in breast cancer

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成果类型：

期刊论文

作者：

Hu, Haihong;Yan, Ting;Zhu, Hongxia;Zhan, Wendi;Zhang, Jingdi;...

通讯作者：

Zhang, TL

作者机构：

[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, Hongxia; Zhang, Jingdi; Wang, Siyu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, Hongxia; Zhang, Jingdi; Wang, Siyu] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Taolan; Zhang, TL] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Phase Clin Trial Ctr 1, Hengyang 421001, Hunan, Peoples R China.

[Yan, Ting] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Lingxiang] Indiana Univ Sch Med, Melvin & Bren Simon Comprehens Canc Ctr, Dept Radiat Oncol, Indianapolis, IN 46202 USA.

通讯机构：

[Zhang, TL ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Phase Clin Trial Ctr 1, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Breast cancer;Immune checkpoint-related genes;Immune infiltration;Immunotherapy

期刊：

CLINICAL AND EXPERIMENTAL MEDICINE

ISSN：

1591-8890

年：

2023

DOI：

10.1007/s10238-023-01247-2

基金类别：

National Natural Science Foundation of China [82003802]; Science and Technology Program of Hunan Health Commission [20201978]; China Scholarship Council [201808430085]; Clinical Research 4310 Program of the First Affiliated Hospital of the University of South China [20224310NHYCG04]; Science and technology innovation Program of Hengyang City [202250045223]; Natural Science Foundation of Hunan Province [2019JJ50542, 2023JJ50156]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Breast cancer is one of the most prevailing forms of cancer globally. Immunotherapy has demonstrated efficacy in improving the overall survival of breast cancer. The aim of us was to formulate a novel signature predicated on immune checkpoint-related genes (ICGs) that could anticipate the prognosis and further analyze the immune status of patients with breast cancer. After acquiring data, we pinpointed the definitive ICGs for constructing the prognostic model of breast cancer. We constructed a novel prognostic model and created a fresh risk score called Immune Checkpoint-related Risk Score in ...

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A novel immune checkpoint-related signature for prognosis and immune analysis in breast cancer

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