Regulatory T and CXCR3+ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19 - 成果

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Regulatory T and CXCR3⁺ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zheng, Xingyu;Lu, Rui;Pan, Dong;Peng, Liting;He, Rongzhang;...

通讯作者：

Qu, XW

作者机构：

[Zheng, Xingyu; Liu, Fen; Qu, Xiaowang; Wu, Chanfeng; Lu, Rui; Xie, Tianyi; Liu, Wenpei] Univ South China, Coll Basic Med, Hengyang Med Sch, Hengyang, Peoples R China.

[Zheng, Xingyu; Chen, Jun; Wang, You; Liu, Fen; Tang, Jinyong; Pan, Dong; Tang, Yinggen; Wu, Chanfeng; Teng, Shishan; Peng, Liting; Lu, Rui; He, Rongzhang; Hu, Yabin; Rong, Xiaohan; Xie, Tianyi] Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Hengyang Med Sch, Chenzhou, Peoples R China.

[Wang, You] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Qu, Xiaowang] Univ South China, Coll Basic Med, Hengyang Med Sch, 28 West Changsheng Rd, Hengyang 421001, Peoples R China.

通讯机构：

[Qu, XW ] U

Univ South China, Coll Basic Med, Hengyang Med Sch, 28 West Changsheng Rd, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

COVID-19;Circulating T-Follicular Helper Cell;Neutralizing Antibody;Regulatory T cell

期刊：

JOURNAL OF INFECTIOUS DISEASES

ISSN：

0022-1899

年：

2024

DOI：

10.1093/infdis/jiae061

基金类别：

National Natural Science Foundation of China [92269115, 82061138020, 32270996, 82102365]; Science and Technology Program of Hunan Province China [2022RC3079]; Natural Science Foundation of Hunan Province China [2021JJ40006, 2022JJ30095]; Education Department of Hunan Province [21A0529]; General Project of the Health Commission of Hunan Province [D202302076189]; Graduate Research and Innovation Project of Hunan Province [CX20221024, 213YXC019]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Regulatory T (Treg) cells are involved in the antiviral immune response in patients with coronavirus disease 2019 (COVID-19); however, whether Treg cells are involved in the neutralizing antibody (nAb) response remains unclear. Here, we found that individuals who recovered from mild but not severe COVID-19 had significantly greater frequencies of Treg cells and lower frequencies of CXCR3+ circulating T follicular helper (cTfh) cells than healthy controls. Furthermore, the frequencies of Treg and CXCR3+ cTfh cells were negatively and positively correlated with the nAb responses, respectively, a...

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Regulatory T and CXCR3⁺ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19

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