HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Ting;Zeng, Chong;Song, Zhihao;Liu, Qing;Chen, Si;...

通讯作者：

Huang, Wei;Li, HY;Huang, W;Ma, QQ

作者机构：

[Hu, Ting; Song, Zhihao; Huang, Wei; Liu, Qing; Li, Haoyu] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Peoples R China.

[Hu, Ting; Song, Zhihao; Liu, Qing; Li, Haoyu] Inst Skull Base Surg & Neurooncol Hunan Prov, Changsha 410008, Peoples R China.

[Hu, Ting; Song, Zhihao; Huang, Wei; Liu, Qing; Li, Haoyu] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

[Zeng, Chong] Univ South China, Affiliated Hosp 7, Hengyang Med Sch, Dept Med, Changsha 410119, Peoples R China.

[Chen, Si; Li, Haoyu] Cent South Univ, Xiangya Hosp, Dept Ophthalmol, Changsha 410008, Peoples R China.

通讯机构：

[Huang, W ; Huang, W; Li, HY ] C

[Ma, QQ ] P

Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Peoples R China.

Inst Skull Base Surg & Neurooncol Hunan Prov, Changsha 410008, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

语种：

英文

关键词：

ASCL1;HNRNPA2B1;HNRNPR;N6-methyladenosine (m6A);Neuroblastoma

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ISSN：

0925-4439

年：

2024

卷：

1870

期：

页码：

167050

DOI：

10.1016/j.bbadis.2024.167050

基金类别：

CRediT authorship contribution statement Ting Hu: Writing – original draft, Visualization, Validation, Methodology, Investigation. Chong Zeng: Writing – original draft, Visualization, Validation, Methodology, Investigation. Zhihao Song: Visualization, Validation. Qing Liu: Resources, Formal analysis. Si Chen: Software. Wei Huang: Writing – review & editing, Supervision, acquisition, Conceptualization. Qianquan Ma: Writing – review & editing, Supervision, Resources, Conceptualization. Haoyu Li: Writing – review & editing,

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

HNRNPA2B1 and HNRNPR stabilize ASCL1 mRNA in neuroblastoma, but whether their regulatory effects depend on m6A modification and whether their function involves ASCL1 remain unknown. This study investigated the m6A-dependent binding of HNRNPA2B1 and HNRNPR to ASCL1 and subsequent regulation, as well as the expression, clinical significance, and function of HNRNPA2B1 and HNRNPR in neuroblastoma. We revealed that METTL14 mediated ASCL1 m6A modification to stabilize ASCL1. HNRNPA2B1 and HNRNPR significantly enriched ASCL1 mRNA by binding to the 5' and 3' untranslated regions, respectively, and MET...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问