期刊论文

中文

中国公共卫生

1001-0580

2012

28

6

802-804

国家自然科学基金（30670634）；

本校为第一机构

目的 探讨铀矿尘致大鼠肺组织纤维化对血浆中Ⅲ型前胶原氨端肽(PⅢNP)、层粘连蛋白(LN)和转化生长因子-β1(TGF-β1)的影响.方法 60只大鼠随机分为铀矿尘组和对照组,铀矿尘组每只大鼠气管内一次性滴注20 mg/mL粉尘悬液1mL,对照组给予等量生理盐水,分别于处理后第7、14、21、30及60d采取肺组织及外周血,进行肺组织形态学观察及血浆中PⅢNP、LN和TGF-β1含量测定.结果 在染尘后第21、30、60d时,PⅢNP含量为(17.90±1.55)、(19.06±1.62)、(20.09±1.65) ng/mL,LN含量为(81.81±1.32)、(83.64±1.52)、(84.73±2.20)ng/ mL,TGF- β1含量为(34.03±3.21)、(46.65±3.09)、(40.95±3.18) pg/mL,与对照...

Objective To explore the changes of N-terminal propetide of type Ⅲ procollagen(PⅢNP),laminin(LN),and transforming growth factor-β1(TGF-β1) plasma in rats with pulmonary fibrosis induced by uranium dusts.Methods Sixty adult Wistar rats were divided randomly into control group(30 rats)and uranium dust group(30 rats).The intratracheal instillation method was used.Uranium dust group was exposed to 20mg/ml uranium dust suspension 1ml per rat,meanwhile control group was exposed to normal saline 1ml per rat.On the day of 7,14,21,30,and 60 after th...