期刊论文

中文

中国公共卫生

1001-0580

2010

26

9

1140-1142

湖南省教育厅资助项目（09C141）； 湖南省衡阳市科技局资助项目（2009ks28）；

本校为第一机构

目的 探讨甲醛和苯对雄性小鼠生殖系统的联合毒作用和机制. 方法 108只昆明种雄性小鼠随机分为9组, 按3×3析因设计, 甲醛和苯染毒剂量分别为O(对照组), 5, 10 mg/kg和0(对照组), 100, 400 mg/kg, 连续灌胃染毒5d, 35 d后处死, 检测睾丸脏器系数、结构和细胞的凋亡及精子活力、畸型, 睾丸三磷酸腺苷(ATP)酶活性、 Ca~(2+)含量和总抗氧化能力(T-AOC). 结果甲醛和苯联合染毒最高剂量组小鼠精子死亡率、畸型率和睾丸细胞凋亡率分别为(18.56±2.83)%, (22. 03±1.35)%, (9. 76 ±0. 76)%, 高于对照组(P

Objective To explore the joint reproductive toxicity and its mechanism of benzene and formaldehyde in male mice.Methods Totally 108 Kunming male mice were randomly divided into 9 groups according to 3×3 factorial design.Different dose of formaldehyde（0,5,10 mg/kg）,benzene（0,100,400 mg/kg）,and both formaldehyde and benzene were separately given to the mice by gastric gavage for 5 successive days.After 35 days,the mice were sacrificed and their testicular organ coefficient,sperm mortality,malformation rate,testicular morphosis changes,testic...