期刊论文

中文

中国公共卫生

1001-0580

2010

26

7

877-878

湖南省自然科学基金（06jj50052）；

本校为第一机构

目的探讨妊娠期接触甲基叔丁基醚(MTBE)对胎鼠脑组织亚细胞结构和磷酸腺苷(ATP)酶活性的影响. 方法对40只健康成年昆明种小鼠于整个妊娠期间用MTBE,25,100,400,800mg/(kg·bw)进行灌胃染毒,每天1次,给予食用油作为对照组. 测定胎鼠脑组织中ATP酶活性,透射电镜下观察其亚细胞结构. 结果孕鼠MT-BE染毒剂量为25,100mg/(kg·bw)时,胎鼠脑组织中各种ATPase活性较对照组均轻微增强(P>0.05);孕鼠400mg/(kg·bw)染毒时,胎鼠脑组织中Na~+, K~+-ATPase、Ca~(2+)-ATPase、Mg~(2+)-ATPase活性分别为(5.28±0.24),(5.92±0.50),(2.39±0.21)μmol/(mg·prot),与对照组比较明显降低(P

Objective To explore the effect of methyl tertiary-butyl ether（MTBE） on ATPase and ultrastructure of brain tissue of fetal mice during gestation.Methods Forty healthy and pregnant KM mice were distributed in five groups randomly.The MTBE exposure doses were 800,400,100,25 and 0 mg /kg·bw by gavage from the 0 day to the end of gestation,once per day.The levels of ATPase activity were checked and the ultrastructure in the brain tissue of the fetal mice was observed.Results Compared with the control,the level of ATPase activity in brain tissue ...